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PROTO-ONCOGENE PROTEINS C-AKT
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DeCS
Descriptor
English
:
Proto-Oncogene Proteins c-akt
Descriptor
Spanish
:
Proteínas Proto-Oncogénicas c-akt
Descriptor
Portuguese
:
Proteínas Proto-Oncogênicas c-akt
Synonyms
English
:
akt Proto-Oncogene Protein
c-akt Protein
Tree Number:
D08.811.913.696.620.682.700.755
D12.776.476.565
D12.776.624.664.700.168
Definition
English
:
A protein-serine-threonine kinase that is activated by
PHOSPHORYLATION
in response to
GROWTH
FACTORS or
INSULIN
. It plays a major
role
in cell
metabolism
,
growth
, and
survival
as a core component of
SIGNAL TRANSDUCTION
. Three isoforms have been described in mammalian
cells.
History Note
English
:
2006(1987)
Allowable Qualifiers
English
:
administration & dosage
adverse effects
agonists
antagonists & inhibitors
analysis
biosynthesis
blood
cerebrospinal fluid
chemistry
classification
chemical synthesis
contraindications
drug effects
deficiency
diagnostic use
economics
genetics
history
immunology
isolation & purification
metabolism
pharmacology
physiology
pharmacokinetics
poisoning
radiation effects
supply & distribution
secretion
standards
toxicity
therapeutic use
ultrastructure
urine
Record Number:
50724
Unique Identifier:
D051057
Occurrence in VHL
:
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